THE JAK2V617F POINT MUTATION INCREASES THE OSTEOCLAST FORMING ABILITY OF MONOCYTES IN PATIENTS WITH CHRONIC MYELOPROLIFERATIVE NEOPLASMS AND MAKES THEIR OSTEOCLASTS MORE SUSCEPTIBLE TO JAK2 INHIBITION

JAK2V617F is a gain of function point mutation that occurs in Myeloproliferative Neoplasm (MPN) patients and deranges their hemopoiesis at cellular level.We speculate that hyperfunctioning JAK2 can modify osteoclast (OCL) homeostasis in MPN patients.We studied 18 newly diagnosed MPN patients and four age-matched normal donors (ND).Osteoclast formin

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A differential equations model-fitting analysis of COVID-19 epidemiological data to explain multi-wave dynamics

Abstract Compartmental epidemiological models are, by far, the most popular in Track Jacket the study of dynamics related with infectious diseases.It is, therefore, not surprising that they are frequently used to study the current COVID-19 pandemic.Taking advantage of the real-time availability of COVID-19 related data, we perform a compartmental m

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